Loss of Endothelial WWOX: A Risk Factor for ARDS in Smokers?
نویسندگان
چکیده
منابع مشابه
Risk factors for hearing loss in infants: a systematic review
Background and Objective: Hearing loss as a sensory disorder is among the most common developmental disorders. Based on the universal neonatal screening results, the incidence of hearing deficit is 1–3 per 1000 live births in the well-baby nursery population and 2–4 in 100 newborns in the intensive care community. The aim of this study was to highlight the main risk factors for hearing loss bas...
متن کاملLoss of WWOX expression in gastric carcinoma.
PURPOSE WW domain-containing oxidoreductase (WWOX) is a tumor suppressor gene that maps to the common fragile site FRA16D on chromosome 16q23.3-24.1. To investigate the role of the WWOX gene in the development of gastric carcinoma, we examined a large series of primary adenocarcinomas and nine gastric cancer cell lines for the expression of Wwox. EXPERIMENTAL DESIGN Loss of heterozygosity, re...
متن کاملWWOX loss activates aerobic glycolysis
Cancer cells undergo reprogramming of glucose metabolism to limit energy production to glycolysis-a state known as "aerobic glycolysis." Hypoxia-inducible factor 1 (HIF1α) is a transcription factor that regulates many genes responsible for this switch. As discussed here, new data suggest that the tumor suppressor WW domain-containing oxidoreductase (WWOX) modulates HIF1α, thereby regulating thi...
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ژورنال
عنوان ژورنال: American Journal of Respiratory Cell and Molecular Biology
سال: 2021
ISSN: 1044-1549,1535-4989
DOI: 10.1165/rcmb.2020-0444ed